雖然2019年底中國國家希望嚴肅查處科研領域的學術不端，2020年卻有人欺上瞞下、玩忽職守，在2021年推出兩條震撼學術界的論調：
一是大家眾目睽睽之下的圖片造假鐵證，被國際上學術不入流、在國內能玩江湖把戲的人，化解為 「 圖片誤用 」。
二是不懂科學的小官僚有點芝麻大的權力就認為自己可以公然宣稱科學實驗不用重複。
如果這兩條成為中國評判科研學術不端的標準，那麼中國就再無科學研究不端的可能性，有不端也可以同樣輕易化解。
2021年就有成為中國無科研造假元年的危險。這種危險，對中國、中國人民都是危害，只有利於把中國高尚的科學變成低級趣味江湖的小人。
有人假惺惺建議，學術批評只能在英文學術刊物進行，不能有中文文章。其實，這種人的多數（但非百分之百）是寄希望中國大多數人不讀英文，只有英文批評就可以溜過去。
考驗這些人的時間來了：七個國家、三十幾個大學、逾百位科學家一而再地嚴重質疑同一篇文章，在中國，會得到嚴肅調查、嚴格處理嗎？
答案，恐怕很不確定。
元年剛被宣布中國無造假，笑話又來了，雖然可能是黑色笑話。
2021年4月7日，美國、英國、澳大利亞、日本、加拿大、比利時、捷克等7個國家、三十幾個大學、逾百位科學家（包括華裔科學家）發表文章，再次批駁中國科學院上海神經科學研究所楊輝研究員與2013年發表的《細胞》論文。
簡而言之，2013年楊輝的論文普遍不能被重複。
科學界常常就算了，沒有人糾結這種。
但是，可能是因為被浪費時間和資源太多而氣不過，一些科學家義憤填膺聯合執筆於2019年發表批評2013年論文。 2021年楊輝發表對批評的反駁。 2021年這些科學家再反駁。
活的太久了，沒有見過七個國家、三十幾個大學、超過百位科學家反复質疑同一篇文章。
這位楊輝，2020年4月在《細胞》還有一篇文章，被加州大學付向東教授質疑是偷付向東實驗室的想法，而這篇文章最近也被哈佛大學、霍普金斯大學的著名美國教授懷疑，並有多位華人教授質疑可靠性（見：https://mp.weixin.qq.com/s/AIdZ7k3dm8AlQZB0WFyi9A）。
但願中國人的科研文章被 「 七個國家、三十幾個大學、超過百位科學家反复質疑 」只有這空前的一次，而絕後。
對於楊輝2013年文章的批評、反駁、再批評見：https://mp.weixin.qq.com/s/zEjXr6YUBzLWNgog9lu9pQ。
楊輝的文章和批評文章，批評楊輝的科學家名單：
Yang H, Wang H, Shivalila CS, Cheng AW, Shi L, Jaenisch R (2013) One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell154:1370-1309. https:// doi.org/10.1016/j.cell.2013.08.022.
Gurumurthy CB, O’Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, et al. (2019) Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Genome Biology20:171. https://doi.org/10.1186/s13059-019-1776-2.
Yang H, Wang H, Jaenisch R (2021) Response to 「 Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation 」. Genome Biology 22:98.
Gurumurthy, C.B., O’Brien, A.R., Quadros, R.M. et al. (2021) Response to correspondence on 「 Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation 」. Genome Biology 22:99
1. Mouse Genome Engineering Core Facility, Vice Chancellor for Research Office, University of Nebraska Medical Center, Omaha, NE, USA
Channabasavaiah B. Gurumurthy, Rolen M. Quadros & Donald W. Harms
2. Developmental Neuroscience, Munroe Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, NE, USA
Channabasavaiah B. Gurumurthy
3. Transformational Bioinformatics, Health and Biosecurity Business Unit, CSIRO, Sydney, Australia
Aidan R. O’Brien
4. Department of Immunology and Infectious Disease, the John Curtin School of Medical Research, The Australian National University, Canberra, Australia
Aidan R. O’Brien, Jing Gao, Nay-Chi Khin, Jenna Lowe, Nikki Ross, Lora Starrs & Gaetan Burgio
5. Texas A&M Institute for Genomic Medicine (TIGM), Texas A&M University, College Station, TX, 77843, USA
John Adams Jr, Johnathan Ballard, Amy Gonzales, Huiping Guo, Benjamin Morpurgo & Andrei Golovko
6. Department of Immunology, Tufts University School of Medicine, Boston, USA
Pilar Alcaide, Francisco Carrillo-Salinas & Ane M. Salvador
7. RIKEN BioResource Research Center, Tsukuba, Ibaraki, 305-0074, Japan
Shinya Ayabe, Mizuho Iwama, Koji Nakade, Toshiaki Nakashiba, Kenichi Nakashima, Yuichi Obata & Atsushi Yoshiki
8. Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA
Surinder K. Batra, Imayavaramban Lakshmanan & Moorthy P. Ponnusamy
9. Departments of Anatomy and Cell Biology, Human Genetics and Pediatrics, Research Institute McGill University Health Center (RI-MUHC), Montreal, Canada
Marie-Claude Beauchamp, Wesley Chan, Loydie Jerome-Majeweska & Sabrina Shameen Alam
10. Maine Medical Center Research Institute (MMCRI), Scarborough, ME, USA
Kathleen A. Becker, Victoria DeMambro, Anyonya Guntur, Anne Harrington, Michelle Karolak, Volkhard Lindner, Katherine Motyl, Leif Oxburgh, Ilka Pinz, Clifford J. Rosen, Larisa Ryzhova & Lucy Liaw
11.Transgenesis and Animal Modeling Core Facility, Centre de Recherche du Centre Hospitalier Universitaire de Montreal (CRCHUM), Montreal, Canada
Guillaume Bernas, Mariette Ouellet & Jean-Francois Schmouth
12. Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK
David Brough & Catherine B. Lawrence
13. School of Medicine, Indiana University, Indianapolis, IN, 46202, USA
Hanying Chen
14. South Australian Health & Medical Research Institute and Department of Medicine, University of Adelaide, Adelaide, Australia
Ruby Dawson, Sandra Piltz & Paul Thomas
15. Transgenic mouse core facility, VIB Center for Inflammation Research, Ghent, Belgium
Jinke D’Hont, Katrien Staes, Leen Vanhoutte, Frederique Vanrockeghem & Tino Hochepied
16. Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
Jinke D’Hont, Katrien Staes, Leen Vanhoutte, Frederique Vanrockeghem & Tino Hochepied
17. Unit of Cardiac Physiology, School of Medical Sciences, Manchester Academic Health Science Center, University of Manchester, Manchester, UK
Katharine Dibb & Andrew Trafford
18. High-Throughput DNA Sequencing and Genotyping Core Facility, Vice Chancellor for Research Office, University of Nebraska Medical Center, Omaha, USA
James D. Eudy & Ronald J. Redder
19. University of Rochester Medical Center, Rochester, NY, 14642, USA
Lin Gan & Joseph M. Miano
20.Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
Kathryn E. Hentges
21. Transgenic Unit core facility, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Neil Humphreys & Antony D. Adamson
22.Department of Basic Medicine, Division of Basic Medical Science and Molecular Medicine, School of Medicine, Tokai University, 143, Shimokasuya, Isehara, Kanagawa, 259-1193, Japan
Shiho Imai & Taiji Matsusaka
23.Department of Medical Data Science, Osaka University Graduate School of Medicine, Suita, Japan
Hideshi Ishii
24.The University of Texas, MD Anderson Cancer Center, Houston, TX, USA
Eric Jonasch, Xian-De Liu, Chad Smith, Xuesong Zhang & Jan Parker-Thornburg
25.Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester AND Manchester Heart Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
Bernard Keavney
26.Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, Osaka, Japan
Masamitsu Konno
27.The Institute of Experimental Animal Sciences, Osaka University Graduate School of Medicine, Osaka, Japan
Yuko Kotani, Yayoi Kunihiro, Yoshiki Miyasaka, Yoshihiro Uno, Yuko Yamauchi, Kazuto Yoshimi & Tomoji Mashimo
28.Centre de Recherche du Centre Hospitalier Universitaire de Montreal (CRCHUM), Montreal, Canada
Catherine Larochelle
29.Children’s Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA
Lin Li, Yu Zhang & Hao Zhu
30.Manchester Collaborative Centre for Inflammation Research (MCCIR), School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
Gloria Lopez-Castejon
31. Centre for Biological Timing, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Andrew Loudon
32.Center for Matrix Biology and Medicine, Graduate School of Medicine, Tokai University, Isehara, Kanagawa, 259-1193, Japan
Hiromi Miura & Masato Ohtsuka
33.Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, School of Medicine, Tokai University, 143, Shimokasuya, Isehara, Kanagawa, 259-1193, Japan
Hiromi Miura & Masato Ohtsuka
34.Laboratory of Molecular Life Science, Foundation for Biomedical Research and Innovation, Kobe, Japan
Yo-ichi Nabeshima
35.Department of Laboratory Animal Science, Support Center for Medical Research and Education, Tokai University, 143, Shimokasuya, Isehara, Kanagawa, 259-1193, Japan
Sanae Ogiwara
36.Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX37LE, UK
David Ray
37.Mouse Biology Program, University of California, Davis, USA
Mark T. Ruhe, Brandon J. Willis, K. C. Kent Lloyd & Joshua A. Wood
38.Laboratory of Transgenic Models of Diseases and Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
Radislav Sedlacek & Petr Kasparek
39.College of Osteopathic Medicine, Marian University, Indianapolis, IN, 46222, USA
Karan Sharma
40.Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Japan
Fumihiro Sugiyama, Satoru Takahashi & Seiya Mizuno
41. Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Tomohiro Tanaka
42.Department of Physical Therapy, School of Health and Human Sciences, Indiana University, Indianapolis, IN, 46202, USA
Christian S. Wright, Xin Yi & William R. Thompson
43.Lillehei Heart Institute Regenerative Medicine and Sciences Program, University of Minnesota, Minneapolis, MN, USA
Satyabrata Das & Daniel J. Garry
44.Paul and Sheila Wellstone Muscular Dystrophy Center, University of Minnesota, Minneapolis, MN, USA
Daniel J. Garry
45.Department of Surgery, School of Medicine, University of California, Davis, Davis, USA
K. C. Kent Lloyd
46.McGill Integrated Core for Animal Modeling (MICAM), Montreal, Canada
Mitra Cowan
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